Weight Loss and GLP-1
nausea on retatrutide, is it the dose or the speed
AmberVial388/11 Jun 2026/1105 views
Coming off a long tirzepatide run and switched over about seven weeks ago. Female, 34, started this leg at 82 kg, currently 76.8 kg. Went in at 1 mg weekly for four weeks, which was uneventful, then up to 2 mg. The 2 mg weeks have been noticeably rougher than anything I had on tirzepatide at comparable relative doses. Nausea starting around 18 hours post injection and running through most of the next day, plus a heart rate that is sitting maybe 8 to 10 bpm above my normal resting when I check it in the morning. The heart rate thing is what made me post. I know some elevation is described with this class, but I would like to hear from people who have tracked it rather than people who have read about it. My question is whether nausea like this is a signal that 2 mg is my ceiling for now, or whether it is a signal that I moved up too fast and my body would have handled 2 mg fine if I had spent longer at 1 mg or gone through something in between. Those two situations look identical from the inside and I cannot tell which one I am in. Practical things that have helped: injecting Friday evening so the worst day is Saturday when I do not have to be functional. Eating something small and bland before rather than going in on an empty stomach. Ginger, which I assumed was nonsense and which appears to do something. Things that have not helped: trying to power through a long run on the bad day. That was miserable and I nearly passed out on a hill in Newlands.
4 replies
11 Jun 2026
No experience on reta but the Friday evening injection timing is such a good idea that I am stealing it. I have been doing Sunday mornings which means my worst stretch lands on Monday at work.
12 Jun 2026
I have tracked resting heart rate through a reta run because I am a runner and I look at that number obsessively anyway. Mine went up about 6 bpm on average and it stayed up for the duration, then came back down within roughly two weeks of stopping. So your 8 to 10 is in the range other people describe. That said, I would not treat "other people also had this" as reassurance on its own. Sustained resting heart rate elevation is a thing worth mentioning to a doctor, particularly if you have any family history. It is cheap to get checked and expensive to guess wrong. On your question, I lean towards speed rather than ceiling. Four weeks at 1 mg then straight to 2 mg is a doubling. Some people run an intermediate step, and if you had spent another two or three weeks at 1 mg before moving you might have had a smoother time. But I want to be clear that this is me reasoning from how these things generally behave, not something I know.
13 Jun 2026
Adding the moderator caveat since heart rate has come up. Nausea is unpleasant and mostly self-limiting. Persistent resting heart rate elevation is a different category of thing and it belongs in a conversation with a clinician, not on a forum. Nobody here can examine you, nobody here has your history, and none of us should be telling you whether 8 to 10 bpm is fine for you specifically. Please do not read the replies above as clearance to carry on. Read them as "this is common, now go get it looked at". Also worth flagging: if nausea ever tips into persistent vomiting, or you get severe upper abdominal pain radiating to the back, that is a stop-and-seek-help situation rather than a push-through one.
18 Jun 2026
Booked for the 26th. Holding at 2 mg until then rather than dropping back, since the nausea has eased a bit this past week which possibly answers my own question.
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