Protocols and Dosing
does splitting BPC into two daily doses make a difference
StoicReagent735/08 Apr 2026/916 views
Genuine question about protocol design rather than a "does it work" question. BPC-157 has a short half life. Depending on which source you believe it is somewhere in the region of a few hours subcutaneously, and some of the estimates are considerably shorter than that. So the standard advice of 250 to 500 mcg twice daily makes sense on paper, you are trying to keep something in the system rather than spiking once and having nothing for twenty hours. But then TB-500 gets dosed at something like 2 to 2.5 mg twice a week and nobody splits that, because the fragment hangs around much longer. Completely different pharmacokinetics, same shelf, same forum. So my question: has anyone here run the same total daily BPC dose as one shot versus split into two and noticed a difference? I am running 500 mcg total daily for an achilles thing and I currently do 250 in the morning and 250 around 8pm. Week 5. Improving, but slowly enough that I cannot tell placebo from signal. I am also aware that "I split it and it worked" proves nothing since almost nobody runs the control. I mostly want to know if anyone has done one, then the other, on the same injury. Secondary thing. I have read people saying to time it around training, either right before so it is peaking during load, or right after during the repair window. Both arguments sound plausible which usually means neither is well supported. I have been doing mine in the morning regardless of when I train, which is between 6am and 7am four days a week and evenings on Saturdays. Achilles is right side, mid-portion tendinopathy, been managing it for about fourteen months, heavy slow resistance work three times a week which is doing more than anything else has.
4 replies
08 Apr 2026
I have run both on the same elbow, about eight months apart, which is the closest thing to what you are asking for that I can offer and it is still a bad experiment. Single 500 mcg morning dose for six weeks, then later 250 twice daily for six weeks. Second run felt better but my loading programme was also better by then, so I would not put weight on it. On timing around training: I would not overthink it. Consistency beats cleverness with something you are running daily for eight weeks. The version you will still be doing at 6am on a cold Wednesday is the correct version. The heavy slow resistance is doing the work by the way. Mid-portion achilles responds to that better than almost anything, and 14 months of it is where the real signal is.
09 Apr 2026
Splitting for me was more about tolerating it than about pharmacokinetics. 500 mcg in one go made me feel a bit off for an hour, slightly flushed and heavy headed. Two lots of 250 and nothing. Could be placebo honestly, but it was consistent enough over a few weeks that I stopped questioning it.
11 Apr 2026
Mildly disagreeing with the framing here. Week 5 on a fourteen month tendinopathy and you are calling improvement "slow" is a bit harsh on yourself. Tendon remodelling is measured in months. Collagen turnover in tendon is famously sluggish compared to muscle. I would give it the full twelve weeks with the loading programme unchanged before you conclude anything about split versus single dose. Changing the protocol at week 5 because you are impatient is how you end up with four half-experiments and no answer.
14 Apr 2026
Fair, and probably correct. Leaving it alone until week 12 then. Will post the boring version of this with numbers when I get there.
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